Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2011, Issue 7, Pages 1233-1241Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201001627
Keywords
Embelin; Natural products; Chemical libraries; Suzuki-Miyaura coupling; Quinones
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- Council for Scientific and Industrial Research (CSIR)
- Indo French Centre for the Promotion of Advanced Research (IFCPAR)
- Ligue contre le Cancer [35]
- Region Bretagne
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The synthesis of new derivatives of embelin, a natural inhibitor of X-linked inhibitor of apoptosis protein (XIAP) is described. The design of these new molecules involved introduction of aromatic groups directly linked to the benzoquinone core. To allow a large flexibility in the nature and the length of the added chain, the strategy involves first a Suzuki-Miyaura reaction with functionalized aromatics, yielding a first generation of molecules. Then, by appropriate use of the functional groups, a second generation of representative embelin derivatives was prepared.
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