Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2011, Issue 35, Pages 7097-7106Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201101190
Keywords
Asymmetric synthesis; Zirconium; Lactones; Natural products
Categories
Funding
- Irish Research Council for Science, Engineering and Technology (IRCSET) EMBARK Initiative
- Programme for Research in Third-Level Institutions (PRTLI)
- Higher Education Authority
- University College Dublin
- Higher Education Authority's PRTLI
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The d-lactone-containing natural product (+)-tanikolide, a brine shrimp toxin and antifungal compound, was synthesized in nine steps with an overall yield of 26.4?% by employing Sharpless asymmetric epoxidation and ZrCl4-catalyzed intramolecular acetalization as the key steps. The novel beta-methyl-substituted analogues of (+)-tanikolide and()-malyngolide have also been prepared by using the same asymmetric synthetic approach.
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