Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2012, Issue 4, Pages 817-823Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201101406
Keywords
Click chemistry; Macrocycles; Nitrogen heterocycles; Copper; Carbohydrates
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Funding
- Region Champagne-Ardenne
- Centre National de la Recherche Scientifique (CNRS)
- Institut National de la Recherche Agronomique (INRA) [RDR1 CP2D]
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A convenient approach to the construction of a galacturonic acid based macrocycle containing an amide group and a triazole ring has been achieved. The key step relies on the efficient formation of a 16-membered ring by a copper-catalysed intramolecular cycloaddition reaction applied to analkyne-azide galacturonate. Depending on the reaction conditions, the outcome of the 1,3-dipolar cycloaddition varied; the expected intramolecular 1,4-triazole was obtained as well as a C2-symmetric dimer in different ratios. A preliminary study of the complexation properties of this macrocycle towards CuII cations revealed the formation of cryptates in a 1:1 metal/ligand ratio.
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