Copper-Catalyzed Domino One-Pot Synthesis of 2-(Arylselanyl) arylcyanamides

Domino C-Se cross-coupling of 2-(iodoaryl)selenoureas with aryl iodides has been accomplished in the presence of a copper(I)-1,1-phenanthroline complex at moderate temperature. The reactions involve intra-and intermolecular C-Se cross-coupling to give the substituted 2-(arylselanyl)arylcyanamides. Aryl iodides having electron-donating and -withdrawing substituents are compatible, affording the target selanyl ethers in high yield.