Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 17, Pages 3229-3236Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000125
Keywords
Nucleosides; Olieonucleotides; DNA; Phosphanes; Palladium
Categories
Funding
- European Union [MEXT-2004-014320]
- Wellcome Trust
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Seven phosphane-functionalized deoxyuridines have been prepared by amide bond formation between aminodeoxyuridines and phosphanylcarboxylic acids. X-ray crystal structures for two of these new modified nucleosides have been obtained. The same coupling method has been extended to oligonucleotides. The phosphane containing strands have been purified and characterized by MALDI-TOF and, for the first time, P-31 NMR spectrometry. Coordination of a phosphane-modified 15-mer to a [PdCl(eta(3)-allyl)] moiety has been confirmed by P-31 NMR spectroscopy.
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