Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 15, Pages 2885-2892Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000061
Keywords
Nucleotides; Nucleosides; Phosphorus; Cross-coupling
Categories
Funding
- Centre for New Antivirals and Antineoplastics [1M0508]
- Institute of Organic Chemistry and Biochemistry [AVOZ40550506]
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A series of novel acyclic nucleoside phosphonates with a built-in arylphosphonate moiety has been prepared by a microwave-assisted cross-coupling reaction as the key step. Their cytostatic and antiviral activities were tested. The pK(a) values of the target ortho-, meta- and pare-substituted aryl-phosphonates were determined by P-31 NMR titration studies.
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