4.5 Article

Chan-Lam-Evans Coupling of Cbz-Protected Histidines

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 20, Pages 3811-3814

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000591

Keywords

Copper; Amino acids; Peptidomimetics; Cross-coupling

Funding

  1. Centre National de la Recherche Scientifique (CNRS)
  2. Institut de Chimie des Substances Naturelles (ICSN)
  3. Gif sur Yvette

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Direct functionalization of protected histidines with aryl-boronic acids is described under Chan-Lam-Evans conditions to give the corresponding N(tau)-arylhistidines in moderate to good yields (12 examples, up to 83% yield) under mild conditions.

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