Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 3, Pages 515-522Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200901088
Keywords
Asymmetric synthesis; Ionic liquids; Organocatalysis; Enantioselectivity
Categories
Funding
- National Natural Science Foundation of China [20672061]
- Nankai University State Key Laboratory of Elemento-organic Chemistry
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A novel one-pot three-component asymmetric Mannich reaction using [EMIm][Pro] (1) as a catalyst has been developed. By employing this new reaction system, a variety of optically active beta-amino carbonyl compounds were synthesized in up to 99% yield with up to > 99 dr and > 99% ee The reaction conditions have been optimized and the mechanism for the asymmetric induction IS discussed
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