Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2011, Issue 4, Pages 667-671Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201001479
Keywords
Carbene ligands; Cycloisomerization; Allylic compounds; Gold; Oxygen heterocycles
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Funding
- Deutsche Forschungsgemeinschaft [Ha 1932/9-1]
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Various 2-alkynylallyl alcohols were synthesized by a generally applicable Sonogashira coupling protocol. Subsequent gold-catalyzed transformation was investigated. The use of Au-I catalysts bearing carbene ligands, of either the N-heterocyclic carbene or nitrogen acyclic carbene type, delivered the desired products with low catalyst loadings and under very mild reaction conditions. A broad array of substrates was tested, including alkyl-, alkenyl-, and aryl-substituted alkynes, as well as substrates with two alkynyl moieties. The methodology turned out to have a broad scope. Secondary allyl alcohols were also tolerated, and the resulting trisubstituted furans could be isolated in high yields.
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