Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2011, Issue 3, Pages 463-468Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201001562
Keywords
Natural products; Total synthesis; Cytotoxicity; Antitumor agents
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Funding
- Agency for Science, Technology and Research, Singapore
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In this communication, second-generation analogues of palmerolide A, a recently reported cytotoxic agent against melanoma cancer cells, were rationally designed, synthesized, and biologically evaluated. Structural variations of the enamide side chain and the C1-C8 segment of palmerolide A revealed a narrow structure-activity relationship window of the newly synthesized compounds. In addition, mechanistic and pharmacological studies were performed to assess the therapeutic potential of palmerolide A.
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