Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 33, Pages 6315-6318Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000907
Keywords
Dynamic combinatorial chemistry; Systems chemistry; Aldol reactions; Asymmetric synthesis; Crystallization
Categories
Funding
- Swedish Research Council
- Royal Institute of Technology
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The study of dynamic nitroaldol systems aided the discovery of a diastereoselective crystallization process through amplification of 2-nitro-1-(pyridine-4-yl)propan-1-ol. The phenomenon was further developed into an effective procedure for asymmetic synthesis of pyridine-nitroalcohols and several substrates were screened to this end. These results demonstrate how work with larger dynamic systems facilitates and increases the likelihood of serendipitous discoveries.
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