4.5 Article

1-Substituted Cyclopentylamines from Nitriles and Tetramethylenebismagnesium Dibromide in the Presence of Ti(OiPr)4

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 8, Pages 1574-1578

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200900817

Keywords

Amines; Nitriles; Nucleophilic addition; Grignard reagents

Funding

  1. KAdemCustomChem GmbH
  2. Land Niedersachsen

Ask authors/readers for more resources

Various 1-substituted cyclopentylamines (25 examples, 10-89% yield) have been prepared according to a one-pot procedure by the addition of tetramethylenebismagnesium di-bromide in the presence of Ti(OiPr)(4) to aliphatic, aromatic and heteroaromatic nitriles, respectively.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available