4.5 Article

A Simple and Effective Method for α-Hydroxylation of β-Dicarbonyl Compounds Using Oxone as an Oxidant without a Catalyst

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 36, Pages 7020-7026

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000940

Keywords

Synthetic methods; Oxidation; Hydroxylation; Enols

Funding

  1. National Natural Science Foundation of China [20572046, 20872064]
  2. Program for New Century Excellent Talents in University [NCET-07-0461]
  3. Tianjin Natural Science Foundation [09JCYBJC05900]

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Oxone has been found to be a highly efficient reagent for the introduction of a hydroxy group at the a position of a variety of beta-dicarbonyl compounds in the homogeneous solvent mixture of water and 1,4-dioxane at 60 degrees C.

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