Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 22, Pages 4194-4197Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000615
Keywords
Peptide nucleic acids; Chemical Ligation; Click chemistry; Nucleotides; DNA
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Funding
- University of Wisconsin-Milwaukee (UWM)
- National Institutes of Health
- National Institute on Aging
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A highly efficient chemical ligation was developed for quantitative conjugation of PNA with DNA (PNA or peptide) by using the copper-catalyzed azide-alkyne cycloaddition reaction Whereas PNAs with an alkyne at the C-terminus and an oxide at the N-terminus have been used, an efficient click-click reaction occurs. The PNA click ligation is sequence specific and capable of single nucleotide discrimination
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