Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 12, Pages 2247-2260Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200901302
Keywords
Natural products; Sesquiterpenes; Quadrone; Terpenoids; Total synthesis; Structure-activity relationships
Categories
Funding
- ENS Cachan
- French Research Ministry
- Universite Paul Cezanne
- Centre National de la Recherche Scientifique (CNRS) [UMR 6263]
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Quadranes, discovered with the isolation of (-)-quadrone in 1978, are biologically active naturally occurring sesquiterpenes featuring a distinctive set of bi- to tetracyclic ring systems. The available data for this family of natural products, including isolation data, biosynthetic considerations, a comprehensive compilation of the reported biological activities, and an exhaustive survey of the synthetic work in this area so far, are critically analyzed.
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