Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 1, Pages 47-50Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200901164
Keywords
Chiral Bronsted acids; Enantioselectivity; Friedel-Crafts reaction; Indole; Organocatalysis
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Funding
- National Natural Science Foundation of China [20732006, 20821002, 20932008]
- National Basic Research Program of China [2009CB825300]
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Chiral Bronsted acid catalyzed Friedel-Crafts alkylation of electron-rich arenes with (3-indolyl)methanamines has been realized to provide an efficient synthesis of enantioenriched unsymmetrical triarylmethanes. With 5 mol-% of a newly developed chiral phosphoric acid, the enantioenriched unsymmetrical triarylmethanes were obtained in excellent yields with up to 91 % ee.
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