Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2009, Issue 11, Pages 1698-1706Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200801221
Keywords
Cyclization; Gold; Homogenous catalysis; Hydroalkoxylation; Oxygen heterocycles
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Funding
- Academic Development Program
- Ministerio de Educacion y Ciencia and FICYT (Spain)
- Deutsche Forschungsgemeinschaft for a postdoctoral fellowship
- Universidade de Santiago de Compostela (Spain)
- Cambridge University Chemistry Laboratory
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The AuCl3-catalyzed double hydroalkoxylation of conjugated 7-hydroxyheptynoates offers a convenient route for the synthesis of six-membered cyclic acetals, which are common substructures of polyketide natural products. When conjugated 6-hydroxyhexynoates are used as starting materials, either five-membered cyclic E-enol ethers or the corresponding acetals can be obtained by simply choosing the appropriate reaction solvent. NMR spectroscopic studies were carried out to determine the kinetics and pathway of the latter domino 5-exo cyclization-hydroalkoxylation reaction. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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