Synthesis of Novel Ferrocenyl-Based P,S Ligands (ThioClickFerrophos) and Their Use in Pd-Catalyzed Asymmetric Allylic Substitutions

A series of P,S ligands (ThioChckFerrophos) based on a triazoleferrocenylethyl backbone were synthesized in a four-step sequence by click chemistry methodology. The new P,S ligands were applied in allylic alkylations, etherifications, and animations of 1,3-diphenylprop-2-enyl acetate catalyzed by Pd complexes. These reactions proceeded smoothly to give products in good yields and with good enantioselectivities of up to 90 % ee. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)