Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2009, Issue 28, Pages 4842-4847Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200900691
Keywords
Antitumor agents; Carbohydrates; Platinum; Sugar ethers; Sugar-functionalized complexes
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Funding
- Deutsche Forschungsgemeinschaft [SFB 470, A5]
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Cisplatin, carboplatin, oxaliplatin and further derivatives are worldwide established cytostatics for the treatment of a vast range of tumours. These drugs showed extraordinary success; however, side effects and primary or developed secondary resistance of tumour cells represent severe problems, which prompt the development of novel functionalized platinum complexes. Selectively protected monohydroxy derivatives of glucose and galactose could be etherified by omega-haloethers. Further, Finkelstein reaction and malonate synthesis gave precursor glycoconjugates which were easily transformed into their (diammine) platinum complexes. First tests with different tumour cell lines show biological activity of the gluco-functionalized platinum complex. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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