4.5 Article

Cocatalytic Enzyme System for the Michael Addition Reaction of in-situ-Generated ortho-Quinones

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2009, Issue 3, Pages 358-363

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800791

Keywords

Enzyme catalysis; Laccase; Lipase; Michael addition; Cascade reaction; Quinones

Funding

  1. IPST@GT
  2. Royal Thai Government Scholarship

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A laccase-lipase cocatalytic system was used to catalyze the domino reaction between catechols and nucleophilic reagents including 1,3-dicarbonyl compounds and aromatic amines in aqueous medium at room temperature. Lipase acted as a catalyst for Michael addition step, and also enhanced the overall yield of the final products. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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