4.5 Article

Efficient copper(I)-catalyzed C-S cross coupling of thiols with aryl halides in water

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2008, Issue 4, Pages 640-643

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200700978

Keywords

C-S cross-coupling reactions; copper catalyst; thiols; aryl halides

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CuI efficiently catalyzes the C-S cross coupling of thiols with aryl halides in the presence of tetrabutylammonium bromide in water. The reactions with aryl thiols that have electron-withdrawing and -donating substituents are comparable and afford C-S cross-coupling products in high yield. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008.

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