A Diversity-Oriented Approach to Diphenylalkanes by Strategic Utilization of [2+2+2] Cyclotrimerization, Cross-Enyne Metathesis and Diels-Alder Reaction

A novel and efficient approach towards the synthesis of polysubstituted diphenylalkane derivatives have been demonstrated using a strategic combination of [2+2+2] cyclotrimerization, ethylene cross-enyne metathesis and Diels-Alder reaction as key steps. The strategy involves the stepwise functionalization of acetylenic termini of alpha,omega-diyne scaffold to build functionalized aromatic units. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)