Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2008, Issue 35, Pages 5946-5951Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800765
Keywords
C-C coupling; Gold; Alkynes; Nitrogen heterocycles
Categories
Funding
- National Natural Science Foundation of China [20772043, 20572031]
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Gold(I) iodide catalyzed Sonogashira reactions have been developed. Terminal alkynes reacted with aryl iodides and bromides smoothly in the presence of AuI (1 mol-%) and dppf (1 mol-%) in toluene to generate the corresponding cross-coupling products in good to excellent yields. Furthermore, aromatic terminal alkynes could also react with 2-iodoaniline to form substituted indoles in excellent yields through a coupling-cyclization reaction sequence under the present reaction conditions. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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