Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2008, Issue 19, Pages 3389-3396Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800111
Keywords
concatenated oxazoles; peptides; nitrogen heterocycles; macrocyclization
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Herein is described the synthesis of several oxazole-containing derivatives of IB-01211. The macrocyclization reaction of peptide 14 containing a concatenated triazole was successful and afforded 3 by amide bond formation. However, for those compounds containing quaterazoles or quinqueazoles, the oxazole ring had to be formed during macrocyclization. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
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