Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2008, Issue 20, Pages 3427-3448Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800225
Keywords
alpha,alpha-disubstituted amino acids; constrained amino acids; alpha-substituted prolines; diastercoselectivity; enantio selectivity
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Funding
- NCI NIH HHS [N01 CO012400, N01CO12400] Funding Source: Medline
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This review describes available methods for the diastereoselective and asymmetric synthesis of quaternary prolines. The focus is on the preparation of alpha-functionalized prolines in which the pyrrolidine moiety is not embedded in a polycyclic frame. The diverse synthetic approaches are classified according to the bond that is formed to complete the quaternary skeleton. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
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