The use of solid-phase synthesis techniques for the preparation of peptide-metal complex conjugates

This microreview summarizes recent reports on the preparation of metal complex peptide conjugates by solid-phase synthesis methods. Procedures for such conjugates are in many cases different from standard solid-phase peptide synthesis protocols. Specific advantages of general strategies, the synthesis of peptide-ligand conjugates and complexation with excess metal ions on solid support or the incorporation of previously prepared metal complex amino acid derivatives are discussed. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008.