Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2008, Issue 26, Pages 4391-4399Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200800371
Keywords
nitrogen heterocycles; oxygen heterocycles; spiro compounds; synthetic methods
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The 1-oxa-7-azaspiro[5.5]undecane, 1-oxa-6-azaspiro[4.5]decane, 1-oxa-7-azaspiro[5.4]decane and 1-oxa-6-azaspiro[4.4]nonane ring systems are found as the cores of natural or synthetic products that possess significant biological activities. Because of their potential applications, together with the novelty of their skeletons, these compounds represent challenging targets for chemical synthesis. In this review we summarize the different strategies developed for the synthesis of these spiroaminals. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008.
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