Journal
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Volume 149, Issue 1, Pages 72-76Publisher
ELSEVIER
DOI: 10.1016/j.ejogrb.2009.11.018
Keywords
Metastin; GPR54; PCOS; Adolescent
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Funding
- Medical Science Research Foundation of Guangdong Province [B2007053, B2008042]
- Mega-projects of Science Research for the 11th Five-Year Plan of China [2007BA104B00]
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Objective: This study was designed to: (1) measure metastin levels in women with polycystic ovary syndrome (PCOS) and in adolescent controls; (2) investigate the possible correlations between metastin and PCOS-related reproductive and metabolic disturbances. Study design: The study was a clinical study. Nineteen adolescent women with PCOS, twenty-three adult women with the syndrome, and twenty adolescent controls were selected. Blood samples were collected between day 1 and day 5 of a spontaneous bleeding episode in the PCOS groups and of a menstrual cycle of the controls at 9 a.m. after an overnight fast. Circulating levels of LH, FSH, prolactin, testosterone (T), free testosterone, DHEAS, sex hormone-binding globulin, insulin, glucose and metastin were measured. Result(s): Plasma metastin levels are increased in adolescent women with PCOS compared to adolescent controls. Plasma metastin levels were positively correlated with LH levels, 2-h glucose levels and T levels. Conclusion(s): These results indicate that metastin is increased in adolescent PCOS women. The increased metastin levels were positively correlated with LH and T levels, and may affect the development of PCOS in adolescents. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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