Journal
EUROPEAN JOURNAL OF NUTRITION
Volume 53, Issue 1, Pages 259-267Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-013-0524-8
Keywords
Vitamin D; Vitamin D intake; Vitamin D status; Vitamin D-binding protein; Obesity; 25(OH)D
Categories
Funding
- Novo Nordisk Foundation
- Swedish Research Council [12206]
- Swedish Diabetes Association Research Foundation
- Swedish federal government under the LUA/ALF
- IngaBritt
- Arne Lundbergs Foundation
- Freemasonry Barnhus Board in Gothenburg
- Mary von Sydow Foundation
- Herbert and Karin Jacobsson Foundation
- Wilhelm and Martina Lundgren Foundation
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Obese subjects have lower circulating 25-hydroxyvitamin D (25(OH)D) than normal-weight subjects. Knowledge is scarce regarding differences in vitamin D-binding protein (DBP), free 25(OH)D, and intake of vitamin D between normal-weight and obese subjects. The purpose of this study was to examine intake and vitamin D status in obese compared with normal-weight women. Between September 2009 and October 2011, 43 obese and 43 normal-weight women, 22-45 years of age, mean BMI of 39.1 +/- A 4.6 and 21.6 +/- A 1.8 kg/m(2), respectively, were recruited in the western Sweden region (latitude 57A degrees N). Blood samples, data regarding diet, and sun exposure were collected. DBP concentrations were 320 +/- A 121 and 266 +/- A 104 mu g/mL (P = 0.02) in obese and normal-weight women, respectively. Calculated free 25(OH)D was 13.3 +/- A 5.5 (obese) and 23.7 +/- A 10.7 (normal-weight) (P < 0.001). The obese women had a 20.1 nmol/L lower mean 25(HO)D concentration compared to normal-weight women (P < 0.001). 56 % of obese women and 12 % of normal-weight women had 25(OH)D concentrations a parts per thousand currency sign50 nmol/L. There was no statistically significant difference in total vitamin D intake between the groups. 39 % of the women had a total vitamin D intake < 7.5 mu g/day, the current national recommendation for vitamin D in Sweden. Obese women had higher DBP concentrations compared with normal-weight women and lower free 25(OH)D. The obese women were more likely to have 25(OH)D concentrations that could be considered suboptimal. Vitamin D intake was generally low in normal-weight and obese women of childbearing age.
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