Vitamin D deficiency is an independent predictor of elevated triglycerides in Spanish school children

To determine the association between vitamin D status and the serum lipid profile in children. The subjects of this cross-sectional study were 149 Spanish school children (8-13 years of age). The anthropometric data collected were weight and height, from which the body mass index (BMI) was calculated. Serum 25(OH)D concentrations were measured by chemiluminescent assay. Triglycerides were determined by enzyme colorimetry; total cholesterol and HDL-cholesterol were determined by the cholesterol esterase method. The LDL-cholesterol concentrations were determined mathematically. Compared to children with serum 25(OH)D concentrations in the fourth quartile, those in the first had higher triglyceride (86.0 +/- A 35.7 vs. 64.1 +/- A 26.7 mg/dL; p < 0.05). After adjusting for age, sex, BMI, and physical activity, the serum 25(OH)D level was found to be inversely proportional to the triglyceride (r = -0.857; p = 0.010). While age, sex, BMI, and physical activity explained 12% of the variance of the HDL-cholesterol figures, the inclusion of serum 25(OH)D allowed 23% of the variance to be explained. A low serum vitamin D levels in children is associated with high triglyceride levels.