Journal
EUROPEAN JOURNAL OF NUTRITION
Volume 48, Issue 5, Pages 291-299Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-009-0013-2
Keywords
White adipose tissue; Obesity; Oleoyl-estrone; Visceral fat; Lipogenesis
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Funding
- Fondo de Investigaciones Sanitarias [PI052179]
- Plan Nacional de Investigacion en Biomedicina of the Government of Spain [SAF2006-05134]
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Background Oleoyl-estrone (OE) decreases energy intake while maintaining glucose homeostasis, and energy expenditure at the expense of body fat. White adipose tissue (WAT) depots behave differently under starvation, postprandial state and pharmacologically induced lipolysis. Aim of the study To understand the mechanism of massive lipid loss from WAT elicited by OE treatment. Methods We used overweight male rats. Rats receiving OE (10 nmol/g) gavages were compared with controls and a pair-fed group. Whole fat pads from the mesenteric, retroperitoneal, epididymal and inguinal subcutaneous sites were excised and analyzed for lipid, DNA, mRNA and the expression of lipogenic, fatty acid transporters and lipase genes. Results In OE and pair-fed rats, WAT weights decreased, with the limited loss of cells. Patterns of gene expression in most WAT sites were similar for OE and PF, suggesting a shared mechanism of fat mobilization, but in mesenteric WAT, PF increased lipogenic and fatty acid transporter gene expressions. However, OE inhibited lipogenic expressions more deeply than PF. Conclusions White adipose tissue sites showed different expression patterns, hinting at relatively specialized functions in fat storage; thus, single site analyses cannot be extrapolated to whole WAT. Differences between mesenteric and the other sites suggest that 'visceral fat' should be reserved for this site only, and not applied to other abdominal fat depots (epididymal, retroperitoneal).
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