Journal
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Volume 40, Issue 8, Pages 1283-1291Publisher
SPRINGER
DOI: 10.1007/s00259-013-2408-9
Keywords
Cerenkov; Fluorescence; Multimodal imaging; Image-guided surgery; Nuclear medicine
Funding
- division of Chemical Sciences (CW) of the Dutch Science Foundation (NWO) [VENI 722.011.005]
- NWO-STW-VIDI [STW BGT11271]
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Integration of optical imaging technologies can further strengthen the field of radioguided surgery. Rather than using two separate chemical entities to achieve this extension, hybrid imaging agents can be used that contain both radionuclear and optical properties. Two types of such hybrid imaging agents are available: (1) hybrid imaging agents generated by Cerenkov luminescence imaging (CLI) of beta-emitters and (2) hybrid imaging agents that contain both a radioactive moiety and a fluorescent dye. One major challenge clinicians are now facing is to determine the potential value of these approaches. With this tutorial review we intend to clarify the differences between the two approaches and highlight the clinical potential of hybrid imaging during image-guided surgery applications.
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