Journal
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Volume 38, Issue 9, Pages 1702-1714Publisher
SPRINGER
DOI: 10.1007/s00259-011-1821-1
Keywords
Amyloid; PET; Florbetaben; Alzheimer's disease
Funding
- Bayer Healthcare (Berlin, Germany)
Ask authors/readers for more resources
Purpose Complementing clinical findings with those generated by biomarkers-such as beta-amyloid-targeted positron emission tomography (PET) imaging-has been proposed as a means of increasing overall accuracy in the diagnosis of Alzheimer's disease (AD). Florbetaben ([F-18]BAY 94-9172) is a novel beta-amyloid PET tracer currently in global clinical development. We present the results of a proof of mechanism study in which the diagnostic efficacy, pharmacokinetics, safety and tolerability of florbetaben were assessed. The value of various quantitative parameters derived from the PET scans as potential surrogate markers of cognitive decline was also investigated. Methods Ten patients with mild-moderate probable AD (DSM-IV and NINCDS-ADRDA criteria) and ten age-matched (a parts per thousand yen 55 years) healthy controls (HCs) were administered a single dose of 300 MBq florbetaben, which contained a tracer mass dose of < 5 mu g. The 70-90 min post-injection brain PET data were visually analysed by three blinded experts. Quantitative assessment was also performed via MRI-based, anatomical sampling of predefined volumes of interest (VOI) and subsequent calculation of standardized uptake value (SUV) ratios (SUVRs, cerebellar cortex as reference region). Furthermore, single-case, voxelwise analysis was used to calculate individual whole brain beta-amyloid load. Results Visual analysis of the PET data revealed nine of the ten AD, but only one of the ten HC brains to be beta-amyloid positive (p = 0.001), with high inter-reader agreement (weighted kappa a parts per thousand yenaEuro parts per thousand 0.88). When compared to HCs, the neocortical SUVRs were significantly higher in the ADs (with descending order of effect size) in frontal cortex, lateral temporal cortex, occipital cortex, anterior and posterior cingulate cortices, and parietal cortex (p = 0.003-0.010). Voxel-based group comparison confirmed these differences. Amongst the PET-derived parameters, the Statistical Parametric Mapping-based whole brain beta-amyloid load yielded the closest correlation with the Mini-Mental State Examination scores (r = -0.736, p < 0.001), following a nonlinear regression curve. No serious adverse events or other safety concerns were seen. Conclusion These results indicate florbetaben to be a safe and efficacious beta-amyloid-targeted tracer with favourable brain kinetics. Subjects with AD could be easily differentiated from HCs by both visual and quantitative assessment of the PET data. The operator-independent, voxel-based analysis yielded whole brain beta-amyloid load which appeared valuable as a surrogate marker of disease severity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available