Journal
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Volume 36, Issue 10, Pages 1629-1638Publisher
SPRINGER
DOI: 10.1007/s00259-009-1129-6
Keywords
Pittsburgh compound B; PIB; Arterial sampling; Cerebellum; Parametric images; Amyloid; PET
Funding
- Internationale Stichting Alzheimer Onderzoek (ISAO) [05512]
- American Health Assistance Foundation (AHAF) [A2005-026]
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Purpose The aim of this study was to assess the test-retest variability of [(11)C] PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue. Methods [(11)C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios. Results Test-retest variability was best (similar to 3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values (similar to 10%) were found for plasma input models. Cerebellar V(T) values did not differ significantly between AD and controls. Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [(11)C]PIB PET studies.
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