Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 37, Issue 12, Pages 1896-1902Publisher
WILEY
DOI: 10.1111/ejn.12233
Keywords
amyloid-beta precursor protein; amyloid beta; cross-frequency coupling; gamma rhythm; theta rhythm
Categories
Funding
- Canadian Institute of Health Research (CIHR) [MOP102573, MOP81111]
- Fondation Fyssen
- European Research Executive Agency
- NARSAD
Ask authors/readers for more resources
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by memory impairments. Brain oscillatory activity is critical for cognitive function and is altered in AD patients. Recent evidence suggests that accumulation of soluble amyloid-beta (A) induces reorganization of hippocampal networks. However, whether fine changes in network activity might be present at very early stages, before A overproduction, remains to be determined. We therefore assessed whether theta and gamma oscillations and their cross-frequency coupling, which are known to be essential for normal memory function, were precociously altered in the hippocampus. Electrophysiological field potential recordings were performed using complete hippocampal preparations in vitro from young transgenic CRND8 mice, a transgenic mouse model of AD. Our results indicate that a significant proportion of 1-month-old TgCRND8 mice showed robust alterations of theta-gamma cross-frequency coupling in the principal output region of the hippocampus, the subiculum. In addition we showed that, compared to controls, these mice expressed negligible levels of A. Finally, these network alterations were not due to genetic factors as 15-day-old animals did not exhibit theta-gamma coupling alterations. Thus, initial alterations in hippocampal network activity arise before A accumulation and may represent an early biomarker for AD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available