Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 36, Issue 7, Pages 2941-2948Publisher
WILEY
DOI: 10.1111/j.1460-9568.2012.08220.x
Keywords
LTD; memory; miR-132; perirhinal cortex; Rattus norvegicus
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Funding
- Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
- Engineering and Physical Sciences Research Council [EP/E500110/1] Funding Source: researchfish
- Medical Research Council [G0401403, MC_G0901331, G0700986] Funding Source: researchfish
- MRC [G0401403, G0700986, MC_G0901331] Funding Source: UKRI
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Evidence suggests that the acquisition of recognition memory depends upon CREB-dependent long-lasting changes in synaptic plasticity in the perirhinal cortex.The CREB-responsive microRNA miR-132 has been shown to regulate synaptic transmission and we set out to investigate a role for this microRNA in recognition memory and its underlying plasticity mechanisms. To this end we mediated the specific overexpression of miR-132 selectively in the rat perirhinal cortex and demonstrated impairment in short-term recognition memory. This functional deficit was associated with a reduction in both long-term depression and long-term potentiation. These results confirm that microRNAs are key coordinators of the intracellular pathways that mediate experience-dependent changes in the brain. In addition, these results demonstrate a role for miR-132 in the neuronal mechanisms underlying the formation of short-term recognition memory.
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