Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 33, Issue 6, Pages 1025-1036Publisher
WILEY
DOI: 10.1111/j.1460-9568.2011.07600.x
Keywords
conditional and inducible transgenic; Cre; gene ablation; nestin; reporter mice; tTa
Categories
Funding
- National Sciences and Engineering Research Council of Canada
- Alzheimer Society of Canada
- Heart and Stroke Foundation Centre for Stroke Recovery
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Many laboratories have focused efforts on the creation of transgenic mouse models to study adult neurogenesis. In the last decade several constitutive reporter, as well as inducible transgenic lines have been published that allowed for visualization, tracking and alteration of specific neurogenic cell populations in the adult brain. Given the popularity of this approach, multiple mouse lines are available, and this review summarizes the differences in the basic techniques that have been used to create these mice, highlighting the different constructs and reporter proteins used, as well as the strengths and limitations of each of these models. Representative examples from the literature demonstrate some of the diverse and seminal findings that have come to fruition through the laborious, yet highly rewarding work of creating transgenic mouse lines for adult neurogenesis research.
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