Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 32, Issue 7, Pages 1109-1117Publisher
WILEY
DOI: 10.1111/j.1460-9568.2010.07414.x
Keywords
animal models; deep brain stimulation; depression; psychiatry
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Funding
- NARSAD
- Ontario Mental Health Foundation
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Deep brain stimulation (DBS) is currently being investigated as a therapy for the treatment of depression. Despite promising results of recent clinical trials, neural and chemical mechanisms responsible for the effects of stimulation are still unclear. In this article, we review clinical and laboratory findings on DBS for depression. Particular emphasis will be given to aspects involved in the translation of data from animal models to humans and in our findings on the potential substrates involved in the antidepressant effects of DBS in rats.
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