Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 32, Issue 12, Pages 2087-2095Publisher
WILEY
DOI: 10.1111/j.1460-9568.2010.07525.x
Keywords
growth hormone; in vivo imaging; pituitary; vessels
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Funding
- Agence Nationale de la Recherche (ANR)
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Centre National de la Recherche Scientifique (CNRS)
- University of Montpellier 1
- University of Montpellier 2
- National Biophotonics and Imaging Platform (Ireland) (NBIPI)
- Fondation pour la Recherche Medicale (FRM)
- Reseau National des Genopoles
- Institut Federatif de Recherches
- Region Languedoc Roussillon
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The pulsatile release of hormone is obligatory for the control of a range of important body homeostatic functions. To generate these pulses, endocrine organs have developed finely regulated mechanisms to modulate blood flow both to meet the metabolic demand associated with intense endocrine cell activity and to ensure the temporally precise uptake of secreted hormone into the bloodstream. With a particular focus on the pituitary gland as a model system, we review here the importance of the interplay between blood flow regulation and oxygen tensions in the functioning of endocrine systems, and the known regulatory signals involved in the modification of flow patterns under both normal physiological and pathological conditions.
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