Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 32, Issue 2, Pages 224-230Publisher
WILEY
DOI: 10.1111/j.1460-9568.2010.07353.x
Keywords
axonal and dendritic growth; calcium/calmodulin; circuit; dendritic spine formation; synapse formation
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labour and Welfare of Japan
- Global COE
- Astellas Foundation for Research on Metabolic Disorders
- Naito Foundation
- Cell Science Research Foundation
- Takeda Foundation
- Toray Science Foundation
- Yamada Science Foundation
- Japan Society for the Promotion of Science
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Ca2+-regulated reorganization of actin cytoskeleton is one of the key cell biological events that critically regulate neuronal morphogenesis during circuit formation, spinogenesis during synapse development, and activity-dependent structural plasticity at mature synapses. However, it remains unclear as to what extent the underlying Ca2+ signaling processes are shared or segregated. Here, we present evidence from the literature that collectively begins to suggest that distinct calmodulin-dependent protein kinase (CaMK) isoforms are differentially expressed in time and in subcellular space, and thus may be selectively activated and engaged by distinct upstream stimuli; each CaMK isoform, in turn, couples to related, but separate, cytoskeletal and transcriptional regulatory pathways, dependent on its abundance or physical proximity with either the upstream or downstream signaling complexes. These signal transduction characteristics provide the basis for better understanding the role of excitation-morphogenesis coupling via multiple CaMKs during neuronal circuit and synapse formation.
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