Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 20, Issue 4, Pages 663-670Publisher
WILEY-BLACKWELL
DOI: 10.1111/ene.12019
Keywords
depression; life change events; Parkinson's disease; prospective studies; psychological stress
Categories
Funding
- National Institute of Environmental Health Science [ES10544, U54ES12078, 5P30 ES07048]
- National Institute of Neurological Disorders and Stroke [NS 038367]
- Department of Defense Prostate Cancer Research Program [051037]
- American Parkinson's Disease Association
- Danish Health Insurance Foundation [2009B126]
- Danish Medical Research Council [09-062115]
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Background and purpose Non-motor symptoms including depression are important features of Parkinson's disease (PD). We aim to address the relationship between major life events and depression amongst PD patients free of depressive symptoms at baseline. Methods New-onset PD patients from California were recruited in 20012007 and followed up for 34years. The participants (n=221) were examined by neurologists and responded to comprehensive interviews that included major life events, social support, and coping measures from validated scales. Major depression was assessed using the Structured Clinical Interview for the DSM-IV depression module (SCID). Results More than half of all patients had experienced major life events since diagnosed with PD, and 22 patients developed a major depression. The number of life events was associated with risk of depression in an exposure-dependent manner, with each additional event being associated with a 56% higher risk of depression (95% CI: 1.231.98). Most individual life events were associated with a two- to eight-fold higher risk of depression. Patients with low social support or coping capacities seemed to be particularly susceptible to developing depression after experiencing major life events. Conclusions Life events play an important role for onset of depression in patients with PD; an effect that seems to be modulated by social support and coping capacities and these factors may therefore be important to assess in order to identify patients with PD at high risk of depression and provide effective interventions.
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