Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 18, Issue 3, Pages 538-540Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1468-1331.2010.03164.x
Keywords
association; LRRK2 S1647T; Parkinson's disease; risk
Categories
Funding
- National Natural Science Foundation of China [30770766]
- Guangdong Natural Science Foundation of China [0602123]
- Guangdong Technological Grant [2007B031502003]
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Background: Leucine-rich repeat kinase 2 (LRRK2) S1647T has been identified as a risk variant for Parkinson's disease (PD) in Han Chinese. Methods: To replicate the association of LRRK2 S1647T with risk of PD, we conducted a case-control study of this variant involving 406 PD subjects and 412 controls from southern mainland China. Results: The results showed that the frequency of A allele was higher in patients with PD (OR = 1.238, 95% CI: 1.015-1.510, P = 0.035) compared to controls. In a multivariate logistic regression analysis with the disease group (patients with PD vs. controls) as the dependent variable and genotype as an independent factor adjusting for the effect of age and gender, the homozygous S1647T genotype (AA) was associated with an increased risk of PD (OR = 1.815, 95% CI: 1.270-2.594, P = 0.001). The pooled analysis of present data and the data from the previous work demonstrated that the frequency of A allele was higher in patients with PD (OR = 1.2, 95% CI: 1.09-1.32, P < 0.0001). Conclusions: LRRK2 S1647T increases the risk of Parkinson's disease in southern China.
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