Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 17, Issue 11, Pages 1326-1338Publisher
WILEY
DOI: 10.1111/j.1468-1331.2010.03034.x
Keywords
neurodegenerative diseases; pathophysiology; REM sleep behaviour disorder; sleep disorders; synucleinopathy; tauopathy
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The aim of this review is to provide data on sleep disturbances in three categories of neurodegenerative disorders: synucleinopathies, tauopathies, and other diseases (this heterogeneous group includes also spinocerebellar degeneration and amyotrophic lateral sclerosis). Analysing and knowing sleep disorders in neurodegenerative diseases may offer important insights into the pathomechanism of some of these diseases and calls attention to the still insufficiently known 'sleep neurology'. The identification of sleep disorders in some neurodegenerative conditions may make their diagnosis easier and earlier; for example, rapid eye movements sleep behaviour disorder may precede any other clinical manifestation of synucleinopathies by more than 10 years.
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