Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 159, Issue -, Pages 393-422Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2018.09.055
Keywords
1,8-Naphthalimides; DNA intercalators; Amonafide; Mitonafide; Anticancer agents
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In this review, we describe a detailed investigation about the structural variations and relative activity of 1,8-naphthalimide based intercalators and anticancer agents. The 1,8-naphthalimides binds to the DNA via intercalation, and exert their antitumor activities through Topoisomerase inhibition, photoinduced DNA damage or related mechanism. Here, our discussion focused on works published over the last ten years (2007-2017) related to therapeutic applications, in the order of cancer treatment followed by other properties of 1,8-naphthalimides. In preparing for this review, we considered that several seminal reviews have appeared over the last fifteen years and focused on closely related subjects, however, none of them is exhaustive. (C) 2018 Elsevier Masson SAS. All rights reserved.
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