Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 74, Issue -, Pages 324-332Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.01.008
Keywords
8-Trifluoromethylquinoline; 1,2,3-Triazole; Click chemistry; Suzuki coupling; Antimicrobial activity
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Funding
- Department of Information & Technology, Government of India, New Delhi
- Deanship of Scientific Research at King Saud University [RGP-VPP-207]
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Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a-c, 6a-d and 7a-c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6. (C) 2014 Elsevier Masson SAS. All rights reserved.
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