Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 77, Issue -, Pages 248-257Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.03.011
Keywords
Disulfide bonds; Cyclic peptide; Cyclotide; Grafting
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Funding
- Queensland Government Department of Science, Information Technology, Innovation
- Arts Co-Investment Fund
- Australian Research Council [DP0984390]
- Australian Research Council Linkage grant [LP110200213]
- National 255 Health and Medical Research Council Project grant [APP1009267]
- National Health and Medical Research Council [APP1026501]
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Recently disulfide-rich head-to-tail cyclic peptides have attracted the interest of medicinal chemists owing to their exceptional thermal, chemical and enzymatic stability brought about by their constrained structures. Here we review current trends in the field of peptide-based pharmaceuticals and describe naturally occurring cyclic disulfide-rich peptide scaffolds, discussing their pharmaceutically attractive properties and benefits. We describe how we can utilise these stable frameworks to graft and/or engineer pharmaceutically interesting epitopes to increase their selectivity and bioactivity, opening up new possibilities for addressing 'difficult' pharmaceutical targets. (c) 2014 Elsevier Masson SAS. All rights reserved.
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