Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 77, Issue -, Pages 145-154Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.03.016
Keywords
Multicomponent reactions; Ultrasonic irradiation; Ionic liquids; 1,2,3-Triazole; Antimicrobial activity
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Funding
- UGC, New Delhi, India
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Spirocyclic oxindoles and triazolyl derivatives posses remarkable biological activities. In present work, we have described an efficient one pot four-component domino reaction of 1-(prop-2-ynyl)indoline-2,3-dione, cyclic 1,3-diketones, malononitrile and various aryl azides in DBU based ionic liquids [DBU-H]OAc and [DBU-Bu]OH under ultrasonic irradiation for the construction of heterocycles, comprising spiro-oxindole, 2-amino-4H-pyran, and 1,2,3-triazoles substructures. The antimicrobial activity of all compounds has been investigated against six microbial strains. All compounds showed good antimicrobial activity. All newly synthesized compounds exhibit fluorescence in methanol with large stoke shift. (c) 2014 Elsevier Masson SAS. All rights reserved.
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