Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 83, Issue -, Pages 344-354Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.06.035
Keywords
ACE inhibitors; Calcium channel blockers; Green synthesis; 2-Aminobenzothiazole; Diarylalkylamine; Resistant hypertension
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Funding
- CSIR (SMiLE project)
- Department of Biotechnology (DBT)
- CSIR
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A series of novel 2-(diarylalkyl)aminobenzothiazoles were designed based on commercial synthetic calcium channel blockers (CCBs) and angiotensin converting enzyme (ACE) inhibitors. Which are further modified based on the natural products which are angiotensin converting enzyme (ACE) inhibitors. Completely green protocol was developed for their synthesis. As they are initially designed based on CCBs, they were screened for their ACE inhibition property believing that almost all the compounds will be CCBs. Out of 42 compounds two lead molecules were identified as ACE inhibitors, which were further screened for CCB. As expected both were identified as CCBs with different selectivity over ACE inhibition. Their selectivity over ACE and CCB can be used to treat resistant hypertension. (C) 2014 Elsevier Masson SAS. All rights reserved.
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