Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 71, Issue -, Pages 91-97Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.10.078
Keywords
Benzosuberone; 2, 4-Thiazolidenone; Knoevenagel condensation; Vilsmeier Haack Arnold reaction; Cytotoxicity
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Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi
- [DST-SERB/EMEQ-078/2013]
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Novel representative of the important group of biologically active benzosuberones bearing 2, 4-thiazolidenone moiety was synthesized as potential anticancer agents (6a-j). These compounds were synthesized in good yields from Knoevenagel condensation of compounds 2a-b with thiazolidenone derivatives 3a-e in the presence of sodium acetate and glacial acetic acid. The in vitro cytotoxicity of these compounds was evaluated against different human cancer cell lines (A549, HeLa, MDA-MB-231, MCF-7) and normal cell line, HEK293. Compound 6a exhibited promising cytotoxicity with IC50 values ranging from 2.98 to 13.34 mu M against all the tested cancer cell lines, Hela, A549, MCF-7 and MDA-MB-231, while compound 6g showed potent cytotoxicity against human breast adenocarcinoma cell line (MCF-7, IC50 value of 1.91 mu M). (C) 2013 Published by Elsevier Masson SAS.
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