Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 84, Issue -, Pages 155-159Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.07.004
Keywords
Isatin; Indole; Diethanolamine; Water; 3-Indolyl-3-hydroxy oxindoles; Cytotoxicity
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Funding
- Council of Scientific and Industrial Research, New Delhi
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A series of 3-indolyl-3-hydroxy oxindole derivatives (n = 41) were synthesized by the green aminocatalytic method with excellent yields under mild reaction conditions. All the newly synthesized derivatives were subjected to evaluate their cytotoxic properties against different human cancer cell lines. Results indicated that about 73% of the derivatives exhibited significant anti-proliferative activities against leukemia (U937, THP-1), lung (A549) and breast cancer (MCF7) cell lines. Among them a few of the derivatives exhibited the most potent and effective cytotoxic activities on U937 (34, 36, 38 and 41) and MCF7 (12,35, 40 and 41) cell lines, and their anti-proliferation activities are better than the positive control, Etoposide. (c) 2014 Elsevier Masson SAS. All rights reserved.
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